Xenon Polarizer Delivery to University of Pennsylvania

Xemed has delivered one XeBox xenon polarizing system to the University of Pennsylvania. The research group led by Dr. Rahim Rizi accepted the polarizer upon independently confirming polarization over 48% at a flow rate of 4.5 liters of xenon per hour. Xemed’s XeBox is fully automated, controlled by the end-user through a touch-screen interface for selecting the batch volume, xenon type (natural or isotopically-enriched), and xenon flow rate. After the end-user attaches the desired combination of Tedlar bags (0.25L, 0.5L, 0.75L, 1.0L) onto the four ports, the system can produce up to 3 liters in one batch. Options for xenon flow rates are “slow” (3 liters/hour), “medium” (4.5 liters/hour), or “fast” (6 liters/hour). The MagniXene® contrast agent and XeBox polarizing system, operated with Xemed-supplied 129Xe, connectors, and bags, are recognized by the FDA as a medical drug-device combination.

Hawking Polarizer at UPenn

Figure 1. Xebox Xenon Polarizer operating at UPenn

ABOUT XEMED—We are a product-focused diagnostic drug company with broad expertise and IP in the field of hyperpolarized gases, partnering with clinical researchers and the pharmaceutical industry to advance pulmonary functional MRI through regulatory approval towards worldwide commercial availability.

At Xemed, our mission is to develop inhaled diagnostic agents that are capable of improving the standard of care of respiratory diseases. We will accomplish this by establishing hyperpolarized gas as a scientifically robust, clinically validated, FDA approved, and publically available diagnostic agent for magnetic resonance imaging of lung functional microstructure. We work to demonstrate effectiveness in two fields: 1) guiding clinical management of respiratory diseases, and 2) as a drug development tool to evaluate of the safety and efficacy of new therapies